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Novobiocin, montelukast, and cinnarizine were selected from the screening as promising candidates for experimental testing and all of them exhibited nanomolar inhibitory activity. To this end, different docking models were developed and validated by assessing their pose and score prediction powers. In this regard, we conducted a structure-based virtual screening campaign to find potential TRPV1 modulators among approved drugs, which are known to be safe and thermally neutral. However, thermoregulatory effects associated with the channel inhibition have hampered the path for TRPV1 antagonists to become marketed drugs. In the last few years, it has been proposed as a promising target to develop novel anticonvulsant compounds. We find that DMCPA brutally infringes upon basic human rights such as freedom of speech, sets back the scientific progress and therefore is unacceptable in a free society.The transient receptor potential vanilloid 1 (TRPV1) receptor is a nonselective cation channel, known to be involved in the regulation of many important physiological and pathological processes. Digital Millennium Copyright Protection Act (DMCPA), which prohibits indirect assistance in circumvention of copyright protection.

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